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KMID : 0191120090240040729
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Journal of Korean Medical Science
2009 Volume.24 No. 4 p.729 ~ p.736
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Comparative Study of the Effects of Different Growth Hormone Doses on Growth and Spatial Performance of Hypophysectomized Rats
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Kwak Min-Jung
Park Hee-Ju
Nam Mi-Hyun
Kwon O-Suk
Park So-Young
Lee So-Yeon
Kim Mi-Jin
Kim Su-Jin
Paik Kyung-Hoon
Jin Dong-Kyu
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Abstract
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This study was designed to examine the effects of recombinant human growth hormone replacement on somatic growth and cognitive function in hypophysectomized (HYPOX) female Sprague-Dawley rats. Rats (5 per group) were randomized by weight to 3 experimental groups: group 1, administered 200 μg/kg of GH once daily for 9 days; group 2, administered 200 μg/kg of GH twice daily; and group 3, administered saline daily. Somatic growth was evaluated by measurement of body weight daily and of the width of the proximal tibial growth plate of the HYPOX rats. Cognitive function was evaluated using the Morris water maze (MWM) test. The results indicated that GH replacement therapy in HYPOX rats promoted an increase in the body weight and the width of the tibial growth plate in a dose-dependent manner. On the third day of the MWM test, the escape latency in the GH-treated groups 1 and 2 was significantly shorter than that in the control rats (P<0.001 and P=0.032, respectively), suggesting that rhGH improved spatial memory acquisition in the MWM test. Therefore it is concluded that rhGH replacement therapy in HYPOX rats stimulates an increase in somatic growth in a dose-dependent manner and also has beneficial effects on cognitive functions.
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KEYWORD
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Growth Hormone, Hypophysectomized Rat, Somatic Growth, Cognitive Function, Morris Water Maze Test
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